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Patents: from the McGill lab to the world market

At many universities, like McGill, the seeds of the next great invention could be awaiting discovery—in a student sketchbook, a lab notebook, or on the corner of a professor’s desk. While the allure of invention is strong, the high cost of obtaining a U.S. patent (usually between $20,000-100,000 and sometimes more) often has an inhibiting effect on academic patents.

This may be resolved with a bit of institutional help, according to Associate Director Commercialization Michèle Beaulieu, of the McGill Office of Sponsored Research (OSR). The OSR offers professors at McGill services and support in the realm of intellectual property matters. For example, McGill will cover the cost for inventions that have commercial potential. What’s more, this potential isn’t necessarily restricted to a potential for profit. As evidenced by many McGill inventions, patenting has proved to be instrumental in bringing beneficial and commercially valuable products to market.

“We look at market need. If there is a need that this invention can meet, then yes, it is good enough for us,” said Beaulieu. “Our objective is not to make money, first and foremost; it is to make sure, ultimately, that if a researcher reports an invention to us [and] this invention has potential, that we will try […] to find a way to get this to market so that it will benefit people.”

Dr. Satya Prakash, from the department of biomedical engineering, is one of many McGill professors who have benefited from the intellectual property expertise in the OSR. With a successful company, Micropharma, Prakas has approximately 50 patents to his name.

“They’re very, very supportive,” Prakash said. “We are researchers […] We have no idea how to do these things, they are the first stop.”

However, not every project culminates in a patent. Despite the many resources offered through the OSR, the publications produced at McGill still far outnumber patents. For many professors and students, patenting does not seem to be a priority. However, Prakash thinks it is an integral part of bringing potential products developed by universities to the market.

“Patenting […] in university is very helpful, extremely useful,” Prakash said. “There is no other way [to] bring value to your product. You cannot make it without patenting it, and McGill has a very special program for that through the Office [of Sponsored Research].”

Changes to intellectual property law, currently sweeping the United States, will make patenting even easier. Last month marked the one-year anniversary of President Obama signing the America Invents Act into law. The act, which will take full effect this coming spring, will lead to sweeping and long overdue reforms to U.S. intellectual property law.

This includes a shift from a first-to-invent to a first-to-file system—which will lead to an estimated 22 per cent decrease in the fees required to file for a patent with the United States Patent and Trademark Office­.

The first-to-file system grants a patent to the first inventor to file for a patent. In contrast, the first-to-invent system, seeks to grant patents to the first inventor to conceive an idea. First-to-file is inherently much simpler and cheaper to document.

Regardless of changing international intellectual property laws, the experienced hands at offices like the OSR can make the patenting process and cost manageable. What’s more, these changes are not expected to have much effect on the average McGill inventor attempting to patent their brilliant idea or invention, says Beaulieu.

“The U.S. was the only country that had that requirement, that first-to-invent versus first-to-file. Every[where] else, it is first-to-file. So it has not really changed anything in the way we do business.”

Super soldier ants dwarf worker ants. (flickriver.com)
a, Science & Technology

Freak ants reveal evolutionary truths to researchers

It turns out your high school science teacher was wrong. While evolution can seem like a random series of events, some researchers are arguing that there may be a non-random, or even predictable, aspect to the process.

Ehad Abouheif, Canada research chair in evolutionary developmental biology, and associate professor of biology at McGill, conducts research on ants and the nature of evolution. Ants are ideal for study because they have a complex social hierarchy—workers, soldiers, queens—as well as great diversity, with over 15,000 species.

“Because they are so dramatic, they make phenomenons that are often hard to see in other organisms [obvious], and bring out effects that you could easily miss with a solitary creature,”Abouheif said.

One of his main projects involves super solider ants, vastly larger and stronger than regular soldier ants (the colony protectors), these insects were discovered in the colonies of several species in Arizona. However, Abouheif stumbled upon super soldiers in ant colonies in Long Island, nearly 4,000 km from Arizona. He began studying these colonies, hoping to discover the trait that triggers the transformation.

Abouheif injected larvae with growth hormones at different points in their development, and eventually found the critical moment when the the super soldier gene could be activated. Rather than developing into small, short-lived worker ants, these larvae grew into giant super soldiers. Furthermore, Abouheif found that while few had these giants in their natural colonies, many species of ant larvae could successfully become super soldiers in the lab.

“[Historically], there were super soldiers,” Abouheif said. “Then somewhere in evolution, [ants] lost the phenotypic expression of them, but they retained this potential to produce them; that given some kind of environmental stress, with hormones and nutrition […] you can get the super soldiers to pop out.”

This discovery reinforced Abouheif’s belief that environmental cues play a crucial role in genetic expression, and that freak ants reveal a hidden evolutionary potential that may be present in all species. As humans ingest an increasing amount of growth hormone in food, we could potentially unlock traits only seen in our ancestors.

Another piece of this evolutionary puzzle arose in separate research. Abouheif found an unusual trait in a species of tropical ants: their heads were split down the middle, with one half male and the other female. In another case, the heads were half worker, and half soldier.

Abouheif uncovered a seven-year-old report of the split-head ants on a completely different continent, in a separate species of ant. Digging through older literature, Abouheif came across even more examples.

The split-head trait cannot be entirely genetic, says Abouheif. It is not only due to a mutation in the genome, but also some environmental factor which is changing the way in which the genes are expressed. The fact that this trait occurred and survived in so many isolated colonies was telling to Abouheif.

“We [are] seeing this really rare thing that’s revealing a deep predictability about evolution.”

Discoveries like these are changing assumptions about the random nature of evolution. Super soldiers “are not totally bizarre, random freaks,” but the result of genes from an organism’s ancestry reacting to environmental stimuli.

If evolution is not entirely random, then the ability to predict patterns in genes’ expression will allow for a greater understanding of all organisms, Abouheif says.

“Who knows what kind of potentials we could be activating in humans, other animals, all kinds of things.”

Audrey Moores (chemistry.mcgill.ca)
a, Science & Technology

Audrey Moores: on a quest for ‘greener’ chemistry

Most people associate chemistry with toxic fumes and caustic materials. The Green Chemistry movement, which began in the 1990s, is working to change both the perception and the reality of the field.

  Dr. Audrey Moores, an assistant professor in the McGill department of chemistry, focuses on green chemistry in her research.

“What green chemistry proposes is [that] when you do chemistry, you have to think about health, the environment, and you have to try and design new things that will take this into account much better.”

On September 13, Moores gave a presentation on green chemistry, nanoparticles, and catalysis in the Fall edition of Soup and Science, a lunch lecture series by McGill professors held each semester. Last week, she sat down with the Tribune to discuss her research and the green chemistry philosophy.

“Chemistry used to be focused only on the chemical equation of a chemical reaction itself. Now, it’s considering everything around it:  where are my starting materials coming from? Where is my product going? Where is my waste going? And so on.”

In her lab, Moores’ work focuses on trying to find and design recyclable catalysts. A catalyst is a substance that, when added to a chemical process, makes it more efficient. For example, platinum is a catalyst used in cars to speed up the conversion of carbon monoxide, a toxic gas, into the less harmful carbon dioxide.

“If you have a catalyst, you need to make sure it can be recovered after the reaction and can be reused again and again,” Moores said.  “In trying to design new catalysts, one of the things we use [are] nanoparticles.”

Due to their small size (between 100 and one nm in diameter), each nanoparticle has a high surface area, making them ideal catalysts.

Moores’ lab is focusing on using iron to replace palladium in hydrogenation reactions. Hydrogenation, or the addition of hydrogen to any molecule, is used in many different applications: in the food industry, hydrogenation is used to make margarine.

The problem with using palladium in the reaction is the potential for leaching. The FDA, European Union, and other bodies strongly regulate the quantity of noble metals, like palladium,  in food and pharmacuticals because of their negative health effects.

Iron is a safer alternative and is less likely to leach into the final product. For example, because iron is magnetic, catalysts can be easily extracted  from the lab’s final product. Another huge point in iron’s favour is price: one kilogram of palladium sells for $2,116.44 while the same quantity of iron sells for $0.12.

Finding better alternatives—such as iron instead of palladium—is the goal of green chemistry. However, this process is not always simple.

A big issue in green chemistry is the process of ‘green washing’ or ‘green sheen.’ This is a term for projects in which more money or time has been spent on advertising ‘greenness’ than on environmentally sound practices.

“We want to equip our students with the necessary knowledge to make informed decisions about what is green and what’s not,” said Moores.

Undergraduate students interested in learning more about green chemistry can take CHEM 462, taught by Moores and Professor Chao-Jun Li. The course, Green Chemistry, is offered in the Fall semester, and covers topics such as renewable feedstocks, catalysts and reagents, biocatalysis. It provides students with the opportunity to study in an ever-evolving field.

“We use the term green chemistry, but it really we should call that greener chemistry, because there’s no end to it.” Moores said. “It’s a work in progress.”

Despite the persistent rainfall, protesters marched downtown on Saturday Sept. 22 in a demonstration organized by Coalition Large de l’Association pour un Solidarité Syndicale Étudiante (CLASSE). (Luke Orlando / McGill Tribune)
a, Creative

Vol 32. Issue 4

Latest photos from Issue 4 of 2012-2013.

metrocar.montrealgazette.com
a, News

STM unveils new metro cars to be installed in 2014

On Sept. 21 and 22, the Societé de Transport de Montreal (STM) displayed a full-sized model of Montreal’s upcoming metro trains, named “Azur,” on McGill College Ave. The exhibit was part of “Go Green,” which was held to promote public transportation as well as preview World Car-Free Day, an event held by the STM every Sept. 23 since 2003.

The provincial government granted the contract for 468 new metro cars to the Bombardier-Alstom consortium in Oct. 2010, bypassing the normal bidding process. According to a statement from Quebec Transport Minister Pierre Moreau, the project is expected to generate nearly $400 million in net value added to Quebec’s gross domestic product.

According to Marianne Rouette from STM public affairs, the new metro cars will be delivered beginning in March 2014  at a rate of one train per month, with an expected completion date of Sept. 2018.

“The new “Azur” metro trains will be available [for passenger use]on the Orange line as of Jan. 2015,” Rouette said in French.

The current metro fleet has been in use since 1966—when the metro was first unveiled—and carries an average of 850,000 passengers every weekday. The new metro trains are expected to last a minimum of 40 years.

The metro cars’ new design features larger doors to facilitate the flow of passengers, as well as the possibility of passenger circulation between the metro cars. According to the STM, the latter feature allows for an increase of eight per cent capacity in the metro.

The interior lighting of the metro cars has also been modified, now providing indirect lighting and LED accent lights. A signal built into the doorframes lights up neon green to warn passengers when doors are about to close.

Design by Susanne Wang
Design by Susanne Wang

According to Rouette, the design of the new metro cars incorporated feedback from online surveys accessed by over 24,000 commuters, in addition to mechanics, engineers, and other metro staff.

Some students said they appreciated the chance to walk through the model of the updated metro cars.

“I liked the new metro train—it is very clean and new and it considers a variety of [needs], such as those of handicapped people,” Hannah Aronoff, U3 Latin American studies, said.

Although the new metro trains provide open spaces to accommodate wheelchairs, strollers, and bicycles, some critics have noted that many metro stations still do not have elevators—which prevents certain users from accessing metro stations in the first place.

The current design includes two fold-up seats in each car and 28 fixed seats. Aronoff noted that the design could have made better use of the space by incorporating more fold-up seats, which would increase the seating space while remaining adaptable to universal accessibility requirements if needed.

Roxane Kar, a student visiting Montreal, praised the ergonomic seats.

“The seats are really comfortable—they don’t look that comfortable, but they really are,” Kar said. “Also, the seats stayed plastic, which is good, because when they are not plastic, they get really gross.”

Despite the persistent rainfall, protesters marched downtown on Saturday Sept. 22 in a demonstration organized by Coalition Large de l’Association pour un Solidarité Syndicale Étudiante (CLASSE). (Luke Orlando / McGill Tribune)
a, News

Montrealers take to the streets for free education

On Saturday, students from several Montreal universities and CEGEPs participated in a demonstration for free education organized by the Coalition Large de l’Association pour un Solidarité Syndicale Étudiante (CLASSE). The Service de Police de la Ville de Montréal (SPVM) declared the demonstration illegal, and riot police in the downtown area dispersed demonstrators at around 4:00 p.m., putting an end to the march.

The march began at Parc Lafontaine Avenue and Cherrier Street, where demonstrators gathered at 2:00 p.m. The demonstration was considered by many to be a celebration of the Parti Québécois’ (PQ) recent cancellation of the tuition increase proposed by the previous liberal government, as well as a march towards the broader goal of free education for all.

“This demonstration is about bringing forward a project—to maintain and improve accessibility to higher education [by] bringing down any kind of tuition fees,” Jérémie Bédard-Wien, CLASSE finance secretary, said. “[We want to] improve our university system and make it answer the needs of the population, rather than corporate interests.”

Many students present at the demonstration expressed similar opinions to that of Bédard-Wien.

“What I think a lot of people have failed to realize [is] that for many of us, it wasn’t about tuition fees from the get-go,” Kyle McLaughlin, a third-year anthropology student at Concordia University, said. “It was about trying to build the society that we want to see.”

“I think [education] should be free for everybody,” Jasmine Latendresse, a first-year science student at Collège Lionel-Groulx, said. “It’s a right, and we shouldn’t have to pay for that.”

Bédard-Wien offered suggestions for how free education could become a reality in Québec.

“[Free education] is not a radical idea, as it is often painted by [the] media,” he said. “We could fund such a project [by] improving our fiscal taxation system, [and] perhaps by establishing a capital tax—a very small tax—on financial transactions, that would allow us to bring down user fees in public services, including education. There are also several improvements that can be made in the [financial] management of universities.”

CLASSE did not publish the route of the march in advance, which prompted the SPVM to declare the demonstation illegal, based on municipal by-law P-6—the “prevention of disturbances to the peace, public security and public order.” On their Twitter account, the SPVM confirmed that participants could continue demonstrating, provided that no criminal acts were committed.

SPVM policemen followed the march on foot from the sidewalks.

Until it arrived at the McGill University campus, the demonstration was predominantly peaceful. However, several masked demonstrators dressed in black hurled rocks at police cars parked in front of the Schulich School of Music Building, and jeered at riot police stationed in front of McGill’s Roddick Gates.

Physical confrontations between police and demonstrators broke out at the intersection of Peel and Sherbrooke, causing the demonstration to halt temporarily. Several demonstrators hit and chased police vans on Peel; riot police responded by pursuing the demonstrators in question into the larger crowd.

Following the confrontations, demonstrators reassembled and continued down Drummond Street, where riot police blocked access at several intersections, forcing the march to disperse.

Now that the PQ has frozen tuition, many students are looking to the summit on education—to be held by the PQ in the near future—for more progress. However, many participants in the demonstration had doubts about the intentions of the newly elected government.

“I think governments have to be pushed to have students’ interests in mind,” Bédard-Wien said. “The PQ … wants to index tuition fees to the cost of living, [but] students earning the minimum wage know very well that minimum wage is not indexed to the cost of living. If we are to go to the summit—which has not yet been decided—[we will convey] that any kind of indexation [is] opposed by students.”

“Some could see [the PQ] as an ally, but I personally think that they are still part of the old guard of political parties in this province who have a history of…corruption,” McLaughlin said. “I think they did what was required to get them elected.”

Many participants made it clear they would continue to voice their opinions in the coming months and, perhaps, years.

“[The cancellation of the tuition hikes] is a big step forward for the students, but it’s not where it should stop,” Latendresse said.

“The struggle is not over, and the struggle won’t be over until everyone has access to education everywhere,” McLaughlin said.

a, News

Former MUHC director of human resources under investigation for fraud

Stella Lopreste, the former director of human resources for the McGill University Health Centre (MUHC) super-hospital project, is under investigation by the Unité permanente anti-corruption Québec (UPAC) for allegedly defrauding the facility of $1.6 million.

Last Tuesday morning, UPAC searched the downtown office of the MUHC for information on the handling of contracts for the new super-hospital. This  217,500 square-metre structure is in the process of being built at the former Glen Railyards in Montreal, close to the Vendôme metro station.

Lopreste held her position from 2000 to 2011. According to the CBC, Lopreste allegedly used MUHC funds from 2000 to 2010 to finance personal expenses, such as luxury clothing, independent travel, and electronics.

Additionally, some of the companies working on the super-hospital have been accused of corruption in the past. At the time of press, Lopreste has not been charged.

Affiliated with McGill, the MUHC is a health centre made up of five hospitals throughout Montreal. The super-hospital is a project that will relocate different hospitals—including the Children’s Hospital and the Neurological Institutes—into one complex, so that patients won’t have to travel to different hospitals for specialized care.

Construction began on the super-hospital two years ago, and the entire framework for the hospital complex is complete. Over 1,400 workers and some 350 professionals were working on the project over this past summer.

The UPAC was established in 2011 in order to deal with allegations of corruption, and is investigating some of the contracts awarded in MUHC’s massive $2.35 billion re-development project, which includes the construction of the superhospital, as well as renovations and expansion to the Montreal General Hospital and the Lachine Hospital.

Anne-Frédérick Laurence, a spokeswoman for the police anti-corruption squad, confirmed that investigators seized documents and interviewed staff members during the Tuesday raid. She did not provide further details about what they were looking for.

In a public statement, MUHC confirmed that UPAC came to their offices, requesting information related to the awarding of the contract for the super-hospital public-private partnership.

“The MUHC is cooperating fully with the investigators and has no further comments at this stage,” MUHC Spokesperson Richard Fahey said.

— Christy Frost

The 11th annual Pow Wow featured workshops and traditional dances. (Josh Walker / McGill Tribune)
a, News

11th annual Pow Wow opens Aboriginal Awareness Week

On Sept. 21, McGill’s First People’s House held their 11th annual Pow Wow on Lower Field. With traditional singing and dances, this year’s Pow Wow included a variety of cultural activities to engage students and raise awareness about Aboriginal cultures.

Catching the attention of many passing students, the Pow Wow started off in high spirit, and was an auspicious start to the upcoming Aboriginal Awareness Week, running from Sept. 24 to 28.

“Every year, Pow Wow is getting bigger and better,” Paige Isaac, interim coordinator of McGill’s First People’s House and one of the key organizers of the event, said. “[This year], we did a better job at planning, promotion, and finding new artists… The head dancer, Chris Wysote, actually drove all the way from my community [Listuguj Mi’gmag] just for this event.”

The intermittent rain did little to dampen the excitement afforded by numerous scheduled programs such as Inter-Tribal Dances, Inuit Throat Singing, and Round Dance. Aided by loud speakers, the drumbeats echoed across campus and drew an increasingly large crowd as the event progressed. At the centre of the event, the Aboriginal performers from various North American reserves danced complex steps, wearing patchwork dresses with feathered garments.

The word ‘Pow Wow’ is derived from the Narragansett word ‘powwaw,’ meaning ‘spiritual leader.’ Originally a gathering of North American Aboriginals, it has evolved in recent decades into an event promoting interactions between Aboriginal and non-Aborginal people. Through dances, songs, and speeches, participants were not only exposed to Aboriginal culture, but also encouraged to socialize without the constraints of social barriers and stereotypes.

This year’s Pow Wow sought to pursue such goals with interactive performances such as the Round Dance. In this dance, audience members are encouraged to join hands with performers and dance in circles. Rather than observing from afar, students participated hand in hand with first nations dancers.

(Josh Walker / McGill Tribune)
(Josh Walker / McGill Tribune)

In addition, Pow Wow organized a special workshop to introduce students to a contemporary Aboriginal DJ group, “A Tribe Called Red.” The artists in the group—DJ NDN, DJ Shrub, and Bear Witness—combine traditional drumbeats and throat singing from Cree culture with modern rhythm and melody. The result is a unique style of club music that bridges traditional music with hip-hop, electronica, and house music.

“Traditional Cree drumbeats generally try to get people to dance as wild [sic] as they can, so in a way, it’s perfect for remixing with music today,” DJ NDN said during a question and answer period. “Our process in making music is in many ways trial and error…We synthesize different tones and beats, and keep editing them until they’re ready.”

DJ NDN also emphasized the importance of social media in helping to promote their music.

“The feedback has been very positive,” he said. “We haven’t gotten any bad stereotypes or negative comments on our native influence.”

Outside the workshop, vendors sold a variety of hand-made crafts, accessories, and clothing. Each item had unique patterns, and passing students were intrigued by their creative design and Aboriginal significance.

In an interview with the Tribune, Isaac expressed excitement for the upcoming Aboriginal Awareness Week.

“Everything went according to plan in this year’s Pow Wow,” she said. “We were very happy with the results.”

Pow Wow volunteer Brennan Gordon, U2 arts, said that he’d seen several students volunteering at the event.

“Pow Wow’s been fun,” Gordon said. “This is my first time volunteering [but] I think this helps McGill students find out more about indigenous culture.”

a, News

Senate meeting addresses effect of tuition freeze on students

Last Thursday, McGill Senate convened for the first time this academic year. The meeting included discussion of the Parti Québécois’ (PQ) education platform and its impact on McGill, improvements to the academic advising system, and the annual report on McGill’s policy on harassment, sexual harassment, and discrimination.

Principal Heather Munroe-Blum opened the meeting with remarks on the education platform of the minority PQ government elected during the Sept. 4 provincial election. On Sept. 20, the PQ officially cancelled the previous liberal government’s planned five-year tuition increase, even though universities had already implemented the increase for the fall semester.

Before the official cancellation, Provost Anthony Masi stated that a decree for universities to refund the students would have severe consequences for McGill, as the projected increases were included in the university’s budget plans. According to Masi, the expected total losses for McGill are $90 million, once all five years of the original tuition increase are taken into consideration.

“While we are studying several unpleasant scenarios, until we actually see the alternatives that the new [Quebec government] will put on the table for providing additional revenues to Quebec’s already cash-strapped university system, I am not in a position to indicate the magnitude of cuts that … McGill will have to endure,” Masi said.

At Senate, Munroe-Blum expressed concern for the effects of the losses on the university and its students if the current government does nothing to make up for the gap in the budget.

“A decrease in overall tuition revenue will impact [student support],” she said. “Our current budget is unsustainable.”

Although she did not give exact numbers for the effect on students, Munroe-Blum noted that the loss of tuition revenue will have the greatest impact on out-of province and international students.

“Students who are not from Quebec are not eligible for Quebec student aid, even though a certain percentage of their tuition [goes to Quebec student aid],” Munroe-Blum said. “$55 million net of McGill students goes to the Quebec system.”

Munroe-Blum also emphasized the importance of lobbying the government to ease McGill’s financial situation. According to Munroe-Blum, goals this year include applying for a Special Mission Grant, as well as a Special Infrastructure Grant because of McGill’s unique and historical position in Canada.

Later in Senate, Associate Provost (Policies, Procedures, and Equity) Lydia White presented the annual report of the policy on harassment, sexual harassment, and discrimination. White emphasized the advantages of the university’s internal system, which helps deal with complaints.

“The assumption is that if someone has a complaint [and] is not happy with the outcome, there are other recourses available to them,” White said. “It’s always better to try internal recourse before you go outside. In serious cases they would be referred outside.”

Munroe-Blum added that a strong internal system is advantageous at McGill because of the university’s high international population, since those who are unfamiliar with Quebec law are often more comfortable with pursuing a resolution at the internal level.

Deputy Provost (Student Life and Learning) Morton Mendelson also presented a report to Senate on advancing academic advising at McGill. According to Mendelson, the university has made many improvements in advising in the last two years.

Mendelson said improvements include the creation of an Advising and Mentoring Board and an expansion of the advising website. The administration has also created a student-staff mentoring program, an Aboriginal students advisor, and in-residence advising programs to make advising more accessible to students at times of year when it is in high-demand.

“We have established a platform to go forward,” Mendelson said. “[We need to] seize that moment [and] make strides to go forward in advising, mentoring, and graduate supervision.”

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