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Research Briefs, Science & Technology

Using AI to save lives

Content warning: Mention of suicide and suicidal ideation.

Young people aged 18-29 reported some of the highest rates of depression and anxiety during the COVID-19 pandemic. Even before the social isolation wrought by the pandemic, rates of suicidal ideation among college-aged individuals were troubling: In a 2019 sample survey of 55,000 students, more than 10 per cent reported contemplating suicide in the 12 months prior. 

University students are especially vulnerable to mental health struggles. When they do not have access to appropriate services or support systems, fragile mental health can spiral into self-harm or suicidal tendencies. To prevent such tragedies, identifying primary risk factors for suicidal behaviour is paramount. 

Researchers at McGill and the University of Bordeaux are on their way to doing just that, using machine learning. A new study, published in Scientific Reports, aimed to develop an algorithm to identify factors associated with suicidal thoughts and behaviours. 

The longitudinal study used data from more than 5,000 students in France from 2013-2019, collecting information ranging from lifestyle habits, to sociodemographics, to mental health symptoms. The algorithm then made data-driven predictions, which were compared to the follow-up questionnaires about suicidal thoughts and behaviours. 

Marie Navarro, a PhD student at the University of Bordeaux, performed the statistical analysis for the study. In an interview with The McGill Tribune, Navarro explained the team’s reasons for using machine learning to find predictors. 

“With more classical methods like regression models, you cannot study a lot of factors,  [maximum] twenty, but otherwise, it is complicated,” Navarro said. “With AI, and especially machine learning, we used random forests, [which is] a good algorithm because you can include a lot of factors in your model simultaneously.” 

Random forest algorithms are a type of supervised machine learning typically used to predict outcomes from data patterns—like the future behaviour of a stock, for example. The novelty of machine learning in this context is twofold: Not only does it allow researchers to sift through large amounts of data at once, but it also accounts for the interactions between factors, giving the algorithm better predictive power. 

Indeed, suicidal behaviours do not result from a single, isolated factor; it is often a combination of circumstances. The study found that academic stress and depressive symptoms were top factors for those who identified as women, while self-esteem was one of the most important predictors of suicide risk across gender lines. 

“Some sociodemographic factors, like sex, are already well established as risk factors for suicidal thoughts and behaviours,” Navarro said. “For example, broadly speaking, girls are more likely to report suicidal ideation and even attempts, but more deaths by suicide are reported in boys.” 

Massimiliano Orri, a postdoctoral researcher at McGill and co-author of the paper, believes that universities can benefit from this behavioural data to improve suicide prevention efforts. 

“Universities are uniquely situated to identify youths that need mental health support and help them to have access to care,” Orri wrote in an email to the Tribune. “Today, the wealth of data available and the computational advances such as artificial intelligence provide us with new eyes to identify those youths using simple screening tools that can be easily developed and implemented on a massive scale.” 

The findings suggest that short assessments, perhaps through online, university-administered questionnaires, could reach a broader swath of students who may be hesitant to reach out for help. 

Despite the promising results, Navarro stressed that their work is only a stepping stone to the ultimate goal of harm reduction. 

“This study needs to be replicated and confirmed in other studies, a very important point for research in general, before any application in real life,” Navarro said. “If they are, maybe this kind of analysis can open an interesting target for prevention in the future.” 

If future studies confirm that artificial intelligence techniques like this one are an effective way of identifying at-risk individuals, then this research could result in more powerful screening tools and more lives being saved.

Album Reviews, Arts & Entertainment, Music

Homeshake’s new album ‘Under the Weather’ is a musical rendering of distress and isolation

Homeshake, also known as Peter Sagar, is a Montreal-born and Toronto-based artist known for his mellow sound and poignant lyricism. Under the Weather, his fifth studio album, is a 12-track confession of depression and isolation. Although Sagar wrote the morose album in 2019 after mental health struggles secluded him from the world, its release is timely in the context of a prolonged pandemic. 

“People will probably think that I made Under the Weather during or about COVID-19,” Sagar said. “I was just already living my life that way.” 

Sagar’s lyrics of personal distress are widely relatable. Each track explores a different aspect of depression with lyrics so honest they could be from the artist’s diary. The project’s hazy sound resonates like the fogginess of an anxious brain. Overall, the album is delicate and mellow, with passing songs melting into one another in the same slow, honeyed tempo.

“Oftentimes when you are in a dark place, you are supposed to journal, and that helps release the pressure,” Sagar said. “For me, it always found its way into the music.”

However, such repetition also becomes the album’s main flaw. While some songs rise above the album’s homogenous nature, such as “Passenger Seat” and “Tenterhooks,” others become buried underneath the stronger tracks. “Feel Better” and “Careless,” for example, fail to depart from each track’s formulaic make-up. Still, the album’s consistency does bring a sense of comfort and familiarity, with the melancholia of the album serving as the perfect remedy for the beginning-of-class blues. While the imitative tracklist prevents the album from reaching its full potential, Under the Weather is definitely worth a listen for its empathetically brooding tone.

Arts & Entertainment, Books

Ceilidh Michelle’s ‘Vagabond’ depicts hitchhiking’s joys and tears

It takes days to travel by bus from Montreal to Sacramento, California, and even longer to hitchhike and squat along the state’s coastal highway—the famous California State Route 1. Montreal-based author Ceilidh Michelle’s new novel Vagabond condenses such a quest into just over 200 pages through a series of creative non-fiction vignettes. Vagabond takes readers into the vibrant, yet sometimes unpleasant, adventures that a younger Michelle experiences while wayfaring along the West Coast. Functioning somewhat like a memoir, the stories she tells are genuine and honest, for better or for worse. 

The novel follows a 21-year-old Michelle narrating her journey, starting with her departure from an unhealthy relationship in Montreal to Vancouver, after which travels down south to the United States to pursue her dreams. All the while, Michelle reflects on the sights and scenery, transforming the physical distance she travels into a mental expedition of self-growth. 

In an interview with The McGill Tribune, Michelle spoke about the multiple journeys encapsulated in Vagabond.

“The only difficult part [about writing the book] was trying to stay true to the emotion of each experience,” Michelle said. “I did not want to make anything too melodramatic or overwrought. I really wanted to try and capture things as they [happened]. Some of it is embarrassing, and some of it seems silly to me […] but it’s what happened, and I wanted to stay true to it.”

Michelle meets new friends along every step of her journey, such as the banjo-playing, train-hopping Half-Peach who becomes Michelle’s close companion, as well as individuals worn down by living without homes. Michelle’s encounters with promiscuous drug addicts and unsavoury street bullies paint a somber depiction of living unhoused, reminding readers that her journey is nowhere near as cushioned as that of a university student’s gap year. 

“An undercurrent […] in my writing is affordable housing,” Michelle said. “Home is so important, and it is so essential to feeling human and having dignity.”

Released on Sept. 4 under Douglas & McIntyre, Vagabond is Michelle’s second book. The author’s first title, Butterflies, Zebras, Moonbeams, published through Palimpsest Press in 2020, was shortlisted for 2020’s Hugh McLennan Prize for Fiction. While she was busy pursuing her master of science degree in creative writing at the University of Edinburgh and writing other creative projects, Michelle felt an urge to distill her memories into something more concrete, which led to the spontaneous creation of Vagabond

“I had written a very rough account of what had happened, as it happened, so I already had all of this archival writing to draw from,” Michelle said. “I had [another] project that I was working on with [my agent], and I basically cheated on that prototype and wrote Vagabond instead.” 

Michelle’s narrative takes readers to exciting destinations, whether they be the sometimes-comical streets of Slab City, California’s famous squatter community, or the interior landscapes of a young, curious woman as she learns about herself and the world—each place complete with its own beauty and pain. 

Fans can look forward to Michelle’s upcoming appearances at the Winnipeg International Writers’ Festival Thin Air in September and Junction Reads in January. 

McGill, News, The Tribune Explains

Tribune Explains: Vaccine passports at McGill

As of Sept. 1, accessing non-essential services in Quebec will require a COVID-19 vaccination passport, which is a government proof of full vaccination. While curricular activities at McGill will not require the passport for participation, much of student life will. 

What is the vaccine passport?

The vaccine passport is a Quick Response (QR) code issued by the Quebec government that confirms an individual’s double-vaccination status when scanned via the VaxiCode app. Individuals must present government-issued photo ID and this QR code—either on paper, in PDF format on a mobile device, or on the VaxiCode app—to access non-essential events and services. 

How can students get a vaccine passport?

Fully vaccinated students wishing to obtain a vaccine passport are individually responsible for acquiring this QR code. Those vaccinated in Quebec who have not already received their QR code by email or text can download it online through the Quebec government’s self-service portal.

Those vaccinated internationally or out-of-province must go to a clinic to register their proof of vaccination before downloading their QR code. One can register their out-of-province vaccination either by booking an appointment or by attending a walk-in vaccination clinic, where government-issued photo ID and official proof of vaccination documents are verified. 

The vaccines recognized for the Quebec vaccine passport are Pfizer, Moderna, AstraZeneca/Covishield, and Janssen/Johnson & Johnson; individuals who have received doses of a vaccine excluded from this list can receive an additional dose of an mRNA vaccine in Canada a minimum of 28 days after their last dose. 

How do vaccine passports affect student life?

The list of non-essential activities at McGill that will require the vaccine passport include practising varsity or recreational sports and attending sporting events, concerts, non-curricular academic conferences, and other performances as an audience member. Additionally, students will need the vaccine passport to access fitness centres and common areas in student residences such as TV rooms. Students with vaccine passports will have access to dine-in services while those without passports will only be able to access take-out services.

Students will not need the vaccine passport to access non-curricular or health-related student services, their personal residence rooms, and associated essential common areas such as washrooms, libraries, study hubs, and flex-spaces. 

McGill media relations officer Frédérique Mazerolle wrote to The McGill Tribune about the university’s future plans involving the vaccine passport.

“Our utmost priority has always been the health and safety of our students and staff,” Mazerolle wrote. “McGill has been working with and continues to work with the various government authorities to align with directives, and to adapt our plans and put in place the necessary measures that will ensure the successful return of students and employees to our campuses.

How is the McGill community reacting to this measure?

The vaccine passport mandate has provoked controversy, both about the limits of government power in a pandemic and about how efficient vaccine passports are at limiting the spread of COVID-19. 

Douglas Farrow, a professor of theology and ethics at McGill, expressed his views on vaccine passports in an open letter published on August 30.

“Students, in my opinion, would be very foolish to trade their rights, liberties, and personal autonomy for ‘protection’ they do not need,” Farrow wrote in an email to the Tribune. “That does not work very well, and that puts their health at risk in a new way.” 

In an email to the Tribune, the Students’ Society of McGill University (SSMU)  President Darshan Daryanani explained that he believes the vaccine passport should be needed to access the over 250 clubs and services at McGill, and the large cultural and fundraising events to prevent further outbreaks and campus lockdowns.

“We are here to support the student activities with tools and resources as best we can,” Daryanani wrote. “While the administration claims that a student without a vaccine will ‘miss out on the full and fun McGill experience,’ at SSMU, we hope to provide alternative events to respect the safety of all.”

Off the Board, Opinion

Stop trying to make ‘cheugy’ happen

On March 30, a TikTok user posted about a made-up word she and her friends use to describe things that encapsulate millennial, girlboss, out-of-style energy: Cheugy. Since then, gen-Z-ers have embraced the term, making TikToks and other social media posts about certain cheugy staples––think minions, millennial pink, graphic T-shirts, Rae Dunn home decor, and apparently, jean jackets

Admittedly, the term is a fun addition to our ever-growing arsenal of internet vocabulary, and some may argue that those critical of its use are too sensitive. But below the surface, the word represents a worrying pattern amongst youth to subscribe to popular trends—which are almost always rooted in overconsumption—until they are no longer thought of as cool, at which point those who still enjoy them are seenas out of touch. 

The term cheugy can be tied to another phenomenon––micro-trends. Also known as fads, micro-trends in the fashion world refer to garments or aesthetics that rapidly gain popularity but then just as quickly fall out of style. Some examples of recent micro-trends include exercise dresses, the Y2K “coconut girl” look, and even specific pieces of clothing such as the House of Sunny Hockney Dress

Since these kinds of trends come and go so quickly, keeping up with them can be extremely expensive. This exposes the privilege that comes with being able to adhere to them and, ultimately, to avoid being declared “cheugy.” Of course, the average person who throws around the term is likely not doing so with any intention of making others feel tacky. But the joke risks making lower-income people who are not able to stay on-trend feel inadequate. Especially as young people return to more in-person activities, the pressure to dress a certain way can be amplified. 

The impulse towards this approach to fashion also encourages people to turn to fast fashion more often. Surely, some need to make use of fast fashion due to financial restrictions or limited selection at thrift stores due to sizing. But some who feel the pressure to dress a certain way are more likely to make use of businesses that are notoriously unethical, like SHEIN, to keep up with trends. 

Of course, individual young people cannot necessarily be blamed for this phenomenon. Companies are known to stage elaborate social media campaigns to push their products toward trend status, and most larger businesses make use of psychological manipulation tactics to encourage consumers to purchase the latest new item. Beyond these direct campaigns, the rise of social media influencers plays a role in this as well. For example, Emma Chamberlain, a popular YouTuber, posted a picture on Instagram flaunting yoga pants and Ugg boots—a combination that would have been considered cheugy two years ago—and almost overnight, the influencer had sparked a new trend. This situation is only one of many illustrating how easy it is for tides to change when it comes to fashion. 

But regardless of blame, young people who care about social justice, reducing waste, and overconsumption should be more mindful of their decisions to make fun of those who may be “behind” when it comes to trends in clothing, media consumption, or anything else. Rather than subscribing to fast-paced micro-trends, McGill students should try and hold on to clothing staples they have and like, even if the internet is telling them they have to replace them with something new and shiny. Students can also make use of clothing exchanges and McGill’s free and for sale group. These kinds of individual choices may not end this cycle on their own, but they may be able to influence others on campus to stop caring so much about being on-trend. 

Arts & Entertainment, Film and TV

‘Only Murders in the Building’ refreshingly reinvents the classic murder-mystery story

In a city filled with self-absorbed, isolated, and irritating people, it seems reasonable that New Yorkers rarely interact with their neighbours. Yet Hulu’s newest show Only Murders in the Building proves that boredom is a strong motivator for some to investigate the most despised person in their apartment complex. 

Created by John Hoffman and Steve Martin, this “whodunnit” series focusses on the humour of the mystery, rather than the circumstances of the murder—effectively subverting the traditional murder-mystery genre. Set in the Arconia, a luxurious apartment building in New York, three strangers bond over their love forof the same true-crime podcast—based off of the real podcast Serial— and narrated in the comedy by none other than Tina Fey. Comedy legend Steve Martin plays Charles, a lonely former actor who repulses most people he meets, except for Oliver (Martin Short), a washed-up, over-exuberant Broadway director. Mabel (Selena Gomez), a cryptic young woman, rounds out the comedy trio with dry wit and an ostensibly secret backstory that fills the entire subplot of the series. When the motley bunch learn that fellow tenant Tim Kono (Julian Cihi) has died, they decide to investigate with the sole purpose of creating their own true-crime podcast on the mystery, an obvious satire to the rise of true-crime media in popular culture.

Although Only Murders in the Building prefers cheesy flashbacks over any presentation of serious backstory, the ironic melodrama is bizarre and whimsical. The three unorganized and chaotic “detectives” are charming enough that their unrealistic misadventures add to the storyline. Tiny yet powerfully humorous details, such as Oliver’s intimate relationship with his bulldog, are the cherry on top of the cake. 

The show expertly blends themes of loneliness and failure with its more fantastical elements. Each main character experiences strained family ties, financial distress, and trauma, grounding the show in some of the common anxieties of a post-pandemic world. 

By intertwining comedy with the more complex aspects of the human condition, Only Murders in the Building is a refreshingly relatable modern dramedy. Though only the first three of 10 episodes have been released, the rest of the season is sure to include more comedic moments, plot twists, and hopefully, a solved murder mystery. And if not, releasing the trio’s chaotic true-crime podcast would be an acceptable alternative. 

Viewers can watch Only Murders in the Building on Hulu, where a new episode is released every Tuesday.

Sports

Nine best Olympic logos

Every two years, like clockwork, millions of people collectively spend two weeks with their eyes glued to a screen, rooting for their countries’ athletes and watching thrilling sports until our hearts, and our eyes, bleed. The Olympics have been a celebration of athletic excellence since their founding on a global scale in 1896, when Athens hosted 14 nations and 241 athletes at the first official International Olympic Committee (IOC)-run games.

Situating the Olympics historically can provide an interesting window into the past. While records and medals are often most fondly remembered, the logos of the last 51 Olympiads can tell us about design movements, historical moments, and cultural touchstones—and they are also just cool to look at.

Without further ado, here are nine of The McGill Tribune’s picks for most notable logos from the last 125 years of Olympic history.

London 1948

Although the Olympics began in 1896, their early branding largely consisted of distinct fonts, coats of arms, and travel posters—rather than logos. The 1948 London Summer games featured the first real “logo,” including the iconic five rings, which symbolize the five original participating continents in the inaugural games. The depiction of the Elizabeth Tower resembles a woodblock print and the hands on the clock tower are set to four o’clock—the time of the opening ceremony, demonstrating an incredible attention to detail. The presentation of a famous British landmark was meant to symbolize the power and stability of England coming out of the Second World War.

Cortina d’Ampezzo 1956

The Olympic emblem for the 1956 Italy Winter Games was the first logo to be selected through a design competition. Italian designer Franco Rondinelli used lots of colour—a first in emblem design—while also heeding the requirements of the competition by including the Dolomite mountains and the Olympic rings. This was also the first inclusion of a stylized “snowflake” design, with many others following in the subsequent decades.

Rome 1960

The Rome 1960 logo is majestic and sombre, evoking the ancient history of its host city. Pictured are Romulus and Remus, the feuding twin brothers described in the bloody legend of the founding of Rome. They sit beneath a snarling she-wolf, who, according to legend, found the twin boys abandoned on the river Tiber and nursed them back to life. She stares at the viewer from afar, as if daring us to rise to the Olympic challenge. Of course, this emblem would not be complete without Roman numerals, which only add to its overall mythical impression: It is as if the logo were etched into an ancient stone wall. Indeed, the games themselves have gone down in history for the notable achievements of Abebe Bikila, the first East African to win a gold medal—and who did so running the marathon completely barefoot. 

Tokyo 1964

The Tokyo 1964 logo, one of the most minimal designs on this list, is also one of the most aesthetically pleasing. The logo’s striking colour scheme and bold theme were imprinted on programs and posters throughout the games. The main feature, a red disc with a subtle gradient, is drawn from Japan’s iconic flag, named “Hinomaru.” The flag was only officially adopted in 1870, but its earliest origins date back to the eighth century. The red circle represents the rising sun but is distinct from the controversial Rising Sun flag associated with imperial Japan’s human rights abuses. The design itself was submitted by artist Yusaku Kamekura, whose works mixed Bauhaus influences with traditional eastern designs.

Mexico 1968

This design is a visual delight: The slim parallel lines in the font catch the eye and are exceedingly representative of the design wave of the 1960s. “It was making geometry sing,” said Lance Wyman in an interview with Global Sports Matters, the artist who designed the logo. “It was making it expressive, making it beautiful, making it strong. It had a cultural characteristic when we put it all together.” The insertion of the Olympic Rings into the “68” was not only creative and sleek, but was also prominently featured on the advertising and merchandising of the 1968 Olympics, leading to the production of visually stunning hats, stamps, and posters.

Montreal 1976

This simple, yet pleasant design holds a fond place in many Montrealers’ hearts and is still seared into the city’s core, as much of the park and recreation infrastructure built for the games remain integral parts of the city. The rings extending upwards were emblematic of the prevalent design movement at the time called “Canada Modern.” The centre oval represents the track—often seen as the central sporting event of the Olympic games—the three pillars symbolize the medal podium, and the entire design loosely resembles the Canadian maple leaf. This clean and simple design pervaded the entire aesthetic of the games, and was included on everything from the uniforms to the architecture.

Atlanta 1996

The Atlanta 1996 logo is unique from the others on this list for its vibrant colours and the “100,” marking the Olympic games’ centennial. Designed by Michael Collins, the eye-catching multicoloured stars rising out of the Olympic torch are evocative of ‘90s graphic design trends, that favoured bold colour choices and geometric shapes. The stars also symbolize the athletes’ pursuit of excellence. The deep green background brings to mind the laurel wreaths originally worn by competitors in Ancient Greece, as well as the tree canopy featured in much of Atlanta’s urban landscape. These were exciting Games for McGill and Canada, as McGill graduates Tosha Tsang and Alison Korn won silver in the womens’ rowing eights.

Beijing 2008

The Beijing 2008 logo, entitled “Chinese Seal-Dancing Beijing,” departs from its more clean-cut predecessors with its unique, calligraphy-inspired style. The white figure in motion is etched out of the red—a colour that bears significant cultural meaning in China—and gives the emblem the look of a Chinese seal. The figure not only depicts a dancing athlete but also bears resemblance to the Chinese character “Jing” to represent the host city. That year, Montreal rejoiced as McGill student Thomas Hall won a bronze medal in the men’s 1000m canoe race.

Tokyo 2020

Finally, we return to Japan for another exemplary design, this time a chequered pattern known as “ichimatsu moyo.” The design is said to symbolize prosperity due to the colour pattern continuing indefinitely. The lattice is made up of three different types of shapes to express designer Asao Tokolo’s message of strength in diversity. In addition, the indigo blue is emblematic of Japanese culture due to its use as a dye dating back to the 17th century. Though the games took place in the summer of 2021, the Tokyo 2020 banner remained since merchandise was already being mass-produced before it was postponed for a year.

Research Briefs, Science & Technology

New aortic prosthesis reduces heart surgery operation time

On May 31, a research team at the Montreal Heart Institute (MHI) became the first in Canada to implant a new cutting-edge biological prosthesis into a patient’s heart. The main purpose of the device is to substitute a faulty aortic valve—a valve that regulates blood flow between the heart’s main pumping chamber (left ventricle) and the main artery (aorta). After a defective aortic valve has been removed from the heart, the prosthesis acts as its replacement. 

The novelty of this device is that the replacement tube and valve come pre-assembled, reducing the time patients spend on the operating table and minimizing the risk of technical errors by surgeons. However, according to Renzo Cecere, the director of cardiac surgery at the McGill University Health Centre (MUHC), the new valve generally shares the same design as older models.

“The advantage now is that we have this conduit that comes pre-packaged and pre-built with a biological valve contained within the conduit,” Cecere said in an interview with The McGill Tribune. “But conceptually, there is nothing new or brilliant about this, it just has not been available on the market.” 

Still, the new device is likely to help many patients suffering from aortic valve disease: In 2017, faulty aortic valves accounted for over two-thirds of all valvular heart disease deaths in the United States. 

Valvular heart disease occurs when the aortic valve does not open or close properly. The valve consists of three flaps that open and close together with each heartbeat and acts as a “gatekeeper” by controlling how much blood flows from the heart to the rest of the body. If the valve is diseased, it becomes either too narrow and stiff to fully open (stenosis) or too wide to close completely (regurgitation), causing some blood to flow backwards. Sometimes, valves can also be malformed due to a birth defect called congenital heart disease.  

Given the prevalence of diseased aortic valves, replacing them is a common operation known as the Bentall Procedure. The process involves removing the aortic valve and root and then implanting an artificial tube with a mechanical or biological (tissue) valve inside of it.

Until recently, surgeons have had to sew the valve into the tube before inserting it into the patient’s heart. This step of the procedure is complex, time-consuming, and carries the risk of surgeons making technical errors when stitching the tube and valve together. This new prosthesis, however, eliminates this step with it being pre-assembled and therefore ready to use.

Fortunately, this device will soon be offered to patients in the MUHC: Cecere has already submitted a formal request to acquire it. However, only a select number of patients could qualify as good candidates for this device—even though the MUHC performs about a thousand heart surgeries a year.

“There are a lot of things we do that are quite niche and not high-volume activities,” Cecere said. “But nevertheless, the patients need to be served. It is our obligation to make sure we have the right tools on the shelf.”

For Cecere, this device is further evidence of the remarkable progress that medical technology has made since he became a cardiac surgeon.

“Whether it is in coronary disease, valvular disease, heart failure, or artificial heart technology, all of them have made a tremendous evolution in the last 15 to 20 years,” Cecere said.  Indeed, the first aortic valve replacement was performed in 1962 and now, nearly 60 years later, there is a pre-assembled prosthesis that can be implanted into a patient’s heart in 2.5 hours.

Research Briefs, Science & Technology

McGill researchers set the stage for new triple-negative breast cancer therapy

A cancer diagnosis can radically change the course of a person’s life. Nearly one in two Canadians is expected to develop cancer over their lifetime, and one in four is expected to die from it. Fortunately, physicians have an increasingly effective array of treatments available to counter this devastating disease. 

Three types of receptors are commonly found on the surface of breast cancer tumour cells: Estrogen, progesterone, and HER2 protein receptors. These receptors fuel the growth of cancer cells. Existing therapies can block any of these receptors and successfully stop the growth of the tumour. However, none of these receptors are present in one specific subtype of breast cancer called triple-negative breast cancer (TNBC). It is the most aggressive subtype of breast cancer and it accounts for about 15 per cent of all cases.

The problem with TNBC is that cancer cell growth is not due to any of the three receptors, so current targeted therapies that block the typical receptors are not effective. The way these tumour cells grow is not yet well understood. 

Recently, a team of researchers led by Dr. Jean-Jacques Lebrun, a senior scientist in the Cancer Research Program at the Research Institute of the McGill University Health Centre (RI-MUHC) and a professor of medicine at McGill University, discovered novel mechanisms through which TNBC tumour cells grow. The team used a state-of-the-art gene-editing technology called CRISPR to screen the entire human genome and successfully identified two key pathways that allow TNBC tumours to grow and propagate. 

“There are absolutely no targeted therapies for this type of cancer,” Lebrun said in an interview with The McGill Tribune. “Patients will undergo chemotherapy or radiotherapy, both of which are largely inefficient.”  

The two pathways they identified include an oncogenic pathway named mTOR and a tumour suppressor pathway named Hippo. Both pathways play a role in the regulation of cell growth and programmed cell death, called apoptosis. In TNBC cells, the pathways become abnormally activated, leading to uncontrolled cell growth and tumourigenesis.

The identification of these two growth mechanisms was a major step forward in the search for a TNBC treatment. 

Lebrun and his team subsequently investigated possible ways to interfere with these growth pathways in a recent study published in Nature Communications. They found two potential drugs that would accomplish the necessary interference: Torin1, a drug known to block the mTOR pathway, and verteporfin, a drug normally used for retina eye diseases that can mimic the Hippo pathway.

According to Dr. Meiou Dai, a research associate in the Lebrun Lab at the RI-MUHC and first author of the study, preliminary research has shown some very encouraging results. 

“Torin1 led to growth inhibition on the cell models, and verteporfin was able to induce apoptosis in cancer cells,” Dai said in an interview with the Tribune.

Their results show that these two drugs are effective at countering the growth of TNBC cancer cells. They also demonstrated that both drugs act synergistically and have an even better outcome when used as a combination therapy. 

Lebrun and his team also tested the drugs for other breast cancer subtypes and found that they were all being affected by their combination therapy.

Although this study has paved the way to an effective targeted therapy for TNBC, there is still work to be done before it can become approved. Trials must be conducted on patients to examine the effectiveness of the combination therapy in humans. However, the fact that these are already known drugs is an important advantage. 

“One [verteporfin] is already approved for an eye disease while the second [Torin1] is currently being tested in clinical trials,” Dai said. “This is very important because it should really shorten the time it will take for the proposed combination therapy to be approved and start benefiting patients.”

News

Several McGill professors vocalize demands for vaccine mandate on campus

With the return to in-person classes for the Fall 2021 term, some students have expressed concerns about the McGill administration’s current COVID-19 safety measures, while several faculty members have voiced frustrations about McGill’s proposals for in-person teaching during the Fall. Central to the unease about the administration’s plans for the semester is the ongoing debate about whether the university should implement a COVID-19 vaccine mandate.  

In a media roundtable interview with The McGill Tribune, Christopher Buddle, associate provost (Teaching and Academic Programs), and Fabrice Labeau, deputy provost (Student Life and Learning), spoke of their confidence in the safety measures the university has set in place for the Fall term. 

“I do not want to diminish how people are feeling, because a lot of people are feeling anxious and scared,” Buddle said. “We certainly have heard that from our community. But, we believe and are confident in what we are doing in terms of layers of protection in the classroom environment, so students can feel good about coming in and taking their in-person classes.” 

According to Dr. Nicole Basta, an associate professor in the Department of Epidemiology, Biostatistics, and Occupational Health at McGill, the health guidelines that McGill has in place are insufficient. Basta, along with other McGill professors, is rallying for a stricter approach to preventing the spread of the virus at McGill. 

“Implementing a vaccine mandate is the single most effective policy McGill could implement to protect the entire university community during this fourth wave, which is already underway,” Basta wrote in an email to The McGill Tribune. “Not implementing a vaccine mandate is contrary to all of the scientific evidence we have about how to most effectively increase vaccination rates and how best to prevent the spread of SARS-CoV-2. At the very least, McGill could require routine testing multiple times a week for those who qualify for an exemption from being vaccinated.” 

The administration’s stance against enacting a university-wide COVID-19 vaccine mandate relies on the Quebec government law which states that individuals have the right to refuse consent to medical procedures, with the university’s statement defining vaccinations as such. Labeau explained that while the university can act independently in certain cases, the administration must adhere to provincial legality. 

“We as the university have some autonomy as usual in fulfilling our mission,” Labeau said. “We are bound by a legal framework and so there [are] things that we simply cannot do because of a legal framework. We are definitely trying to stay in line with public health recommendations and making the adaptations that make sense in our context.”

Richard Gold, a professor in the Faculty of Law at McGill, asserts that McGill can, and should, exercise autonomy in implementing a vaccine mandate, given the increasing prevalence of COVID-19’s more contagious Delta variant in Quebec. Gold also argued that the absence of a university-sanctioned vaccination mandate is discriminatory toward faculty and students who are more vulnerable to COVID-19. 

“An analysis [by] 37 professors and teachers from the Faculty of Law concluded that McGill has the full authority to bring in a proof of vaccination requirement and would not violate any constitutional or human rights requirements,” Gold wrote in an email to the Tribune

Gold listed the main reasons why some professors are demanding the implementation of a vaccine mandate at McGill.  

“There are three reasons a proof of vaccination requirement is necessary: [One], given the Delta variant, public health in Quebec has made it clear that we need the population vaccinated at the 90 per cent level; [two], it sends a message to the community that McGill believes in science and medicine and follows the recommendations of its own experts; [three], it provides a concrete reason to the hesitant to be vaccinated now, prior to infection.”

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